Gutkha worth Rs 1 crore was seized on Tuesday from two vehicles in Palghar district near Mumbai, the police said.
Police intercepted the vehicles at Khanivade checkpost in the district, over 100 kms from Mumbai, and found gutkha pouches stashed in several bags, a local police official said without elaborating.
He said the police have detained two drivers.
The police are conducting a joint investigation with the Food and Drug Administration (FDA) department, he said.
The sale and consumption of gutkha and pan masala was banned in Maharashtra in 2012.
The state government had announced earlier this year that sale of gutka would be made a non-bailable offence.