Syrian TV said the bomber detonated his explosives’ vest inside the main judicial building of the justice palace, near the famous Hamidiyeh market in Damascus.
There was no immediate claim for the bombing.
The attack comes on the sixth anniversary of the protests which paved the way for the Syrian conflict and is the second bombing in the Syrian capital in five days.
Twin bomb attacks killed at least 40 in Damascus on Saturday. An Al Qaeda-linked terrorist alliance, Levant Liberation Committee, also known as Hayat Tahrir al Sham, claimed responsibility for the blasts.